Data sheet
| Assay Range | 0.312-20 ng/ml |
| Storage | 2 - 8 ℃ |
| Background | Fatty acid-binding proteins (FABP) are a family of lipid chaperones involved in the transport and metabolism of fatty acids. So far, at least nine members of the family have been identified. FABPs are 14–15 kDa proteins that reversibly bind hydrophobic ligands, such as fatty acids, with high affinity. Heart-type FABP (H-FABP, also known as FABP3) is a cytosolic, low-molecular-weight protein present in abundance in the myocardium, but also in small quantities in the brain, kidney and skeletal muscle. In the case of acute myocardial infarction (AMI), FABP3 is released from the porous cell membranes of ischemic myocardial cells into circulation due to its small size. Therefore, FABP3 is used as a biochemical marker in the early diagnosis of AMI and acute coronary syndrome, and can provide even better sensitivity than other commonly used markers including cTnI, CK-MB, and myglobin 0–6 hours after the onset of chest pain. However, the concentration of FABP3 is affected by age and renal condition. Also, special attention needs to be addressed to additional analytical issues, such as optimum cut-off value. |
| Alternative Name of Analyte | FABP3, FABP11, H-FABP, M-FABP, MDGI, O-FABP, Heart-type fatty acid binding protein, fatty acid binding protein 3 |
| Assay Type | Sandwich ELISA |
| Kit Type | Colorimetric |
| Assay Time | 4.5 hours |
| Sample Type | Serum, plasma, supernatant, cell or tissue lysate. |
| Sensitivity | 0.16 ng/ml |
| Specificity | Native and recombinant FABP3/H-FABP |
| Dilution Factors | undiluted for serum, plasma |
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