Human Klotho beta ELISA

Data sheet

Storage

2 - 8 ℃

Background

This gene encodes a type-I membrane protein that is related to β-glucuronidases. Reduced production of this protein has been observed in patients with chronic renal failure (CRF), and this may be one of the factors underlying the degenerative processes (e

Alternate Names

beta-klotho; BKL; KLB; klotho beta like; Klotho beta;

Assay Type

Sandwich ELISA

Kit Type

Colorimetric

Assay Time

4.5 hours

Sample Type

serum, plasma

Assay Range

62.5 - 4000 pg/ml

Sensitivity

29.1 pg/ml

Specificity

native and recombinant Klotho beta

Recovery

94.8 - 111%

Precision

Inter-assay: 8.7%, Intra-assay: 5.9%

Sample Volume

100 µl

Dilution Factors

varies

Gene ID

152831

Clinical indications

α-klotho can suppress oxidative stress and inflammation, thereby reducing endothelial dysfunction and atherosclerosis. Blood plasma α-klotho is increased by aerobic exercise, thereby reducing endothelial dysfunction.

β-klotho activation of FGF21 protei