Human Klotho/Klotho alpha ELISA

Data sheet

Storage

2 - 8 ℃

Background

Klotho is a transmembrane protein that, in addition to other effects, provides some control over the sensitivity of the organism to insulin and appears to be involved in aging. Its discovery was documented in 1997 by Kuro-o et al. The name of the gene com

Alternate Names

klotho, klotho alpha

Assay Type

Sandwich ELISA

Kit Type

Colorimetric

Assay Time

4.5 hours

Sample Type

serum, plasma

Assay Range

62.5 - 4000 pg/ml

Sensitivity

27.3 pg/ml

Specificity

native and recombinant Klotho protein

Recovery

95.3 - 109%

Precision

Inter assay: 9.3%, Intra-assay: 6.5%

Sample Volume

100 µl

Dilution Factors

undiluted for normal serum

Gene ID

9365

Clinical indications

α-klotho can suppress oxidative stress and inflammation, thereby reducing endothelial dysfunction and atherosclerosis. Blood plasma α-klotho is increased by aerobic exercise, thereby reducing endothelial dysfunction.

β-klotho activation of FGF21 protei