Nuclear Receptor Subfamily 1 Group H, Member 2 Human Recombinant ( NR1H2 Human )

Data sheet

Formulation

Lyophilized from a concentrated (1mg/ml) solution containing 20mM Tris Hcl pH-8 & 0.1% SDS.

Solubility

It is recommended to reconstitute the lyophilized NR1H2 in sterile water & 50ug/ml BSA at a concentration of 1mg/ml, which can then be further diluted to other aqueous solutions.

Purity

Greater than 95.0% as determined by SDS-PAGE.

Description

LXRB Human Recombinant produced in plants is a single polypeptide chain containing 293 amino acids and having a total molecular mass of 31.9kDa. The LXRB is fused to 6xHis Tag at N-terminus and purified by proprietary chromatographic techniques.

Protein Background

NR1H2 regulates the metabolism of cholesterol and bile acids. There are 2 subtypes of LXR, LXR-alpha & LXR-beta. NR1H2 is a ligand-dependent transcription factor that forms heterodimer with the retinoid X receptor. LXR- member of Nuclear Receptor Family i

Expression host

Nicotiana benthamiana.

Synonyms

Liver X receptor beta, LXRB, NER, NER-I.

Stability

Lyophilized LXRB although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution LXRB Human should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to a

Amino acid sequence

HHHHHHSSGIEGRGRLIKHMTPGGSEAGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNKRSFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRMLMKLVSLRTLSSVH

Physical Appearence

Sterile Filtered White lyophilized (freeze-dried) powder.

link

Purified by proprietary chromatographic technique.