C-terminal hemopexin-like domain of MMP-2 Human Recombinant ( PEX Human )

Data sheet

Formulation

The protein was lyophilized with 2mM Tris pH-7.4.

Solubility

It is recommended to reconstitute the PEX in sterile 18M-cm H2O not less than 100ug/ml, which can then be further diluted to other aqueous solutions.

Purity

Greater than 95.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE.

Description

PEX Human Recombinant is expressed as inclusion bodies in E.coli having a molecular mass of 28,453 Dalton and subsequently refolded in vitro to get biological activity.

Protein Background

Recombinant Human PEX (C-terminal hemopexin-like domain of MMP-2) is a noncatalytic Metalloproteinase Fragment with Integrin Binding Activity and can inhibit cell associated collagenolytic activity both in vitro and in vivo. Moreover, PEX can block angiog

Expression host

Escherichia Coli.

Synonyms

C-terminal hemopexin-like domain of MMP-2, PEX.

Reagent Appearance

Sterile Filtered White lyophilized (freeze-dried) powder.

Stability

Lyophilized PEX although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution PEX should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carr

Activity

The bioactivity was measured by HMEC cell line, PEX can inhibit the transmembrane activity of HMEC under the stimulation of VEGF.