Nicastrin, Mouse Anti Human ( NCSTN Antibody )

Data sheet

Clone

PAT3B2AT.

Applications

NCSTN antibody has been tested by ELISA and Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended dilution range for Weste

Protein Background

Nicastrin is a Type I transmembrane glycoprotein which is an integral component of the multimeric gamma-secretase complex. Nicastrin cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein, and may be a stabilizing

Synonyms

Nicastrin, NCSTN, KIAA0253, APH2, RP11-517F10.1.

Type

Mouse Anti Human Monoclonal.

Immunogen

Anti-human NCSTN mAb is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with recombinant human NCSTN amino acids 34-153 purified from E. coli.

Ig Subclass

Mouse IgG2b heavy chain and light chain.

Purification Method

NCSTN antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.

Protein formulation

1mg/ml containing PBS, pH-7.4, & 0.1% Sodium Azide.

Storage Procedures

For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles.

Stability / Shelf Life

12 months at -20°C. 1 month at 4°C.