Fibroblast Growth Factor Receptor 3 Fc Chimera Human Recombinant ( FGFR3 Human )

Data sheet

Formulation

FGFR3 was lyophilized from a concentrated (1 mg/ml) sterile solution containing PBS.

Solubility

It is recommended to reconstitute the lyophilized FGFR-3 in sterile PBS not less than 50ug/ml, which can then be further diluted to other aqueous solutions.

Purity

Greater than 90.0% as determined by:(a) Analysis by silver stain.(b) Analysis by SDS-PAGE.

Description

Soluble FGFR3 Human recombinant fused using a Xa cleavage site with the Fc part of human IgG1 produced in Fc Chimera is a heterodimeric, glycosylated, Polypeptide chain containing 593aa and having a molecular mass of 170kDa.

Protein Background

Fibroblast Growth Factors (FGFs) comprise a family of at least eighteen structurally realted proteins that are involved in a multitude of physiological and pathological cellular processes, including cell growth, differentation, angiogenesis, wound healing

Expression host

Insect Cells.

Synonyms

Achondroplasia, Thanatophoric Dwarfism, CD333, ACH, CEK2, JTK4, HSFGFR3EX, FGFR3.

Reagent Appearance

Sterile Filtered White lyophilized (freeze-dried) powder.

Stability

Lyophilized FGFR3 although stable at room temperature for 3 weeks, should be stored desiccated below -18oC. Upon reconstitution FGFR3 should be stored at 4oC between 2-7 days and for future use below -18oC.For long term storage it is recommended to add a

Amino acid sequence

ESLGTEQRVV GRAAEVPGPE PGQQEQLVFG SGDAVELSCP PPGGGPMGPT VWVKDGTGLV PSERVLVGPQ RLQVLNASHE DSGAYSCRQR LTQRVLCHFS VRVTDAPSSG DDEDGEDEAE DTGVDTGAPY WTRPERMDKK LLAVPAANTV RFRCPAAGNP TPSISWLKNG REFRGEHRIG GIKLRHQQWS LVMESVVPSD RGNYTCVVEN KFGSIRQTYT LDVLERSPHR PI