More info
Overview
Long Name | Antibody Type | Antibody Isotype | Host | Species Reactivity | Validated Applications | Purification |
| signal transducer and activator of transcription 2, 113kDa | Polyclonal | IgG | Rabbit | Human | WB | Immunogen affinity purified. |
Immunogen | ||||||
| A synthetic peptide corresponding to a sequence at the C-terminus of human STAT2(796-814aa RHLNTEPMEIFRNCVKIEE). | ||||||
Properties
Form | Lyophilized |
Size | 100 µg/vial |
Contents | Antibody is lyophilized with 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal and 0.05 mg NaN3. *carrier free antibody available upon request. |
Concentration | Reconstitute with 0.2 mL sterile dH2O (500 µg/ml final concentration). |
Storage | At -20 °C for 12 months, as supplied. Store reconstituted antibody at 2-8 °C for one month. For long-term storage, aliquot and store at -20 °C. Avoid repeated freezing and thawing. |
Additional Information Regarding the Antigen
Gene | STAT2 |
Protein | Signal transducer and activator of transcription 2 |
Uniprot ID | P52630 |
Function | Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state. |
Tissue Specificity | |
Sub-cellular localization | Cytoplasm. Nucleus. Note: Translocated into the nucleus upon activation by IFN-alpha/beta. |
Sequence Similarities | Belongs to the transcription factor STAT family. |
Aliases | Homo sapiens interferon alpha induced transcriptional activator antibody|interferon alpha induced transcriptional activator antibody|ISGF 3 antibody|ISGF3 antibody|MGC59816 antibody|P113 antibody|signal transducer and activator of transcription 2 113kD antibody|Signal transducer and activator of transcription 2 antibody|STAT113 antibody|Stat2 antibody|STAT2_HUMAN antibody |
Application Details
| Application | Concentration* | Species | Validated Using** |
| Western blot | 0.1-0.5μg/ml | Human | AssaySolutio's ECL kit |
AssaySolution recommends Rabbit Chemiluminescent WB Detection Kit (AKIT001B) for Western blot. *Blocking peptide can be purchased at $65. Contact us for more information
Anti-STAT2 antibody, ASA-B1792, Western blotting
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