LRP1 Antibody

Overview

Long Name	Antibody Type	Antibody Isotype	Host	Species Reactivity	Validated Applications	Purification
low density lipoprotein receptor-related protein 1	Polyclonal	IgG	Rabbit	Human	WB	Immunogen affinity purified.
Immunogen
E.coli-derived human LRP1 recombinant protein (Position: A4351-A4544). Human LRP1 shares 86% amino acid (aa) sequence identity with mouse LRP1.

Properties

Form	Lyophilized
Size	100 µg/vial
Contents	Antibody is lyophilized with 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg NaN3. *carrier free antibody available upon request.
Concentration	Reconstitute with 0.2 mL sterile dH2O (500 µg/ml final concentration).
Storage	At -20 °C for 12 months, as supplied. Store reconstituted antibody at 2-8 °C for one month. For long-term storage, aliquot and store at -20 °C. Avoid repeated freezing and thawing.

Additional Information Regarding the Antigen

Gene	LRP1
Protein	Prolow-density lipoprotein receptor-related protein 1
Uniprot ID	Q07954
Function	Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. Required for early embryonic development. Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission.
Tissue Specificity	Most abundant in liver, brain and lung.
Sub-cellular localization	Low-density lipoprotein receptor-related protein 1 85 kDa subunit: Cell membrane; Single-pass type I membrane protein. Membrane, coated pit.
Sequence Similarities	Belongs to the LDLR family.
Aliases	A2MR antibody|Alpha 2 macroglobulin receptor antibody|alpha 2MR antibody|Alpha-2-macroglobulin receptor antibody|APOER antibody|Apolipoprotein E receptor antibody|APR antibody|CD 91 antibody|CD91 antibody|CD91 antigen antibody|IGFBP3R antibody|Low density lipoprotein receptor related protein 1 antibody|Low density lipoprotein related protein 1 antibody|Low-density lipoprotein receptor-related protein 1 intracellular domain antibody|LRP 1 antibody|LRP 515 antibody|LRP 85 antibody|LRP antibody|LRP ICD antibody|LRP-1 antibody|LRP-515 antibody|LRP-85 antibody|Lrp1 antibody|LRP1 protein antibody|LRP1_HUMAN antibody|LRP1A antibody|LRP515 antibody|LRP85 antibody|LRPICD antibody|MGC88725 antibody|TbetaR V/LRP 1/IGFBP 3 receptor antibody|TbetaRV/LRP1/IGFBP3 receptor antibody|TGFBR 5 antibody|TGFBR5 antibody|Type V tgf beta receptor antibody

Application Details

Application	Concentration*	Species	Validated Using**
Western blot	0.1-0.5μg/ml	Human	AssaySolutio's ECL kit

AssaySolution recommends Rabbit Chemiluminescent WB Detection Kit (AKIT001B) for Western blot. *Blocking peptide can be purchased at $65. Contact us for more information