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KCNQ2 Antibody View larger

KCNQ2 Antibody

ASA-B1112

$330.00

More info

Overview

Long Name

Antibody Type

Antibody Isotype

Host

Species Reactivity

Validated Applications

Purification 
potassium voltage-gated channel, KQT-like subfamily, member 2 Polyclonal IgG Rabbit Human, Mouse, Rat WB Immunogen affinity purified.

Immunogen

A synthetic peptide corresponding to a sequence at the N-terminus of human KCNQ2(355-372aa DLHSTWQYYERTVTVPMY), different from the related mouse and rat sequences by one amino acid.

Properties

Form

 Lyophilized

Size

 100 µg/vial

Contents

 Antibody is lyophilized with 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal and 0.05 mg NaN3. *carrier free antibody available upon request.

Concentration

 Reconstitute with 0.2 mL sterile dH2O (500 µg/ml final concentration).

Storage

 At -20 °C for 12 months, as supplied. Store reconstituted antibody at 2-8 °C for one month. For long-term storage, aliquot and store at -20 °C. Avoid repeated freezing and thawing.

Additional Information Regarding the Antigen

Gene

 KCNQ2

Protein

 Potassium voltage-gated channel subfamily KQT member 2

Uniprot ID

 O43526

Function

 Probably important in the regulation of neuronal excitability. Associates with KCNQ3 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs. KCNQ2/KCNQ3 current is blocked by linopirdine and XE991, and activated by the anticonvulsant retigabine. Muscarinic agonist oxotremorine-M strongly suppress KCNQ2/KCNQ3 current in cells in which cloned KCNQ2/KCNQ3 channels were coexpressed with M1 muscarinic receptors.

Tissue Specificity

In adult and fetal brain. Highly expressed in areas containing neuronal cell bodies, low in spinal chord and corpus callosum. Isoform 2 is preferentially expressed in differentiated neurons. Isoform 6 is prominent in fetal brain, undifferentiated neuroblastoma cells and brain tumors.

Sub-cellular localization

 Membrane; Multi-pass membrane protein.

Sequence Similarities

Aliases

 BFNC antibody|BFNS1 antibody|EBN 1 antibody|EBN antibody|EBN1 antibody|EIEE7 antibody|ENB 1 antibody|ENB1 antibody|HNSPC antibody|KCNA 11 antibody|KCNA11 antibody|KCNQ 2 antibody|Kcnq2 antibody|KCNQ2_HUMAN antibody|KQT like 2 antibody|KQT-like 2 antibody|KV7.2 antibody|KVEBN 1 antibody|KVEBN1 antibody|KvLQT 2 antibody|KvLQT2 antibody|Neuroblastoma specific potassium channel alpha subunit KvLQT2 antibody|Neuroblastoma specific potassium channel protein antibody|Neuroblastoma specific potassium channel subunit alpha antibody|Neuroblastoma specific potassium channel subunit alpha KvLQT2 antibody|Neuroblastoma-specific potassium channel subunit alphaKvLQT2 antibody|OTTHUMP00000031681 antibody|OTTHUMP00000031682 antibody|OTTHUMP00000031684 antibody|OTTHUMP00000031685 antibody|OTTHUMP00000031686 antibody|OTTHUMP00000031687 antibody|OTTHUMP00000031689 antibody|Potassium voltage gated channel KQT like protein 2 antibody|Potassium voltage gated channel KQT like subfamily member 2 antibody|Potassium voltage gated channel subfamily KQT member 2 antibody|Potassium voltage-gated channel subfamily KQT member 2 antibody|Voltage gated potassium channel subunit Kv7.2 antibody|Voltage-gated potassium channel subunit Kv7.2 antibody

Application Details

Application Concentration* Species Validated Using**
Western blot 0.1-0.5μg/ml Rat Human, MouseAssaySolutio's ECL kit

AssaySolution recommends Rabbit Chemiluminescent WB Detection Kit (AKIT001B) for Western blot. *Blocking peptide can be purchased at $65. Contact us for more information
Anti-KCNQ2 antibody, ASA-B1112, All Western blotting
All lanes: Anti-KCNQ2(ASA-B1112) at 0.5ug/ml
Lane 1: Rat Brain Tissue Lysate at 40ug
Predicted bind size: 96KD
Observed bind size: 96KD

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