KCNN4 Antibody

Overview

Long Name	Antibody Type	Antibody Isotype	Host	Species Reactivity	Validated Applications	Purification
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4	Polyclonal	IgG	Rabbit	Human, Mouse, Rat	WB	Immunogen affinity purified.
Immunogen
A synthetic peptide corresponding to a sequence at the N-terminus of human KCNN4(14-29aa RRKRLLEQEKSLAGWA), different from the related mouse and rat sequences by two amino acids.

Properties

Form	Lyophilized
Size	100 µg/vial
Contents	Antibody is lyophilized with 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal and 0.05 mg NaN3. *carrier free antibody available upon request.
Concentration	Reconstitute with 0.2 mL sterile dH2O (500 µg/ml final concentration).
Storage	At -20 °C for 12 months, as supplied. Store reconstituted antibody at 2-8 °C for one month. For long-term storage, aliquot and store at -20 °C. Avoid repeated freezing and thawing.

Additional Information Regarding the Antigen

Gene	KCNN4
Protein	Intermediate conductance calcium-activated potassium channel protein 4
Uniprot ID	O15554
Function	Forms a voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization which promotes calcium influx. Required for maximal calcium influx and proliferation during the reactivation of naive T-cells. The channel is blocked by clotrimazole and charybdotoxin but is insensitive to apamin.
Tissue Specificity	Widely expressed in non-excitable tissues.
Sub-cellular localization	Membrane; Multi-pass membrane protein.
Sequence Similarities
Aliases	hIKCa1 antibody|hKCa4 antibody|hSK4 antibody|IK1 antibody|IKCa1 antibody|Intermediate conductance calcium activated potassium channel protein 4 antibody|Intermediate conductance calcium-activated potassium channel protein 4 antibody|KCa3.1 antibody|KCa4 antibody|KCNN 4 antibody|Kcnn4 antibody|KCNN4_HUMAN antibody|Potassium intermediate/small conductance calcium activated channel, subfamily N, member 4 antibody|Putative Gardos channel antibody|SK4 antibody|SKCa 4 antibody|SKCa4 antibody

Application Details

Application	Concentration*	Species	Validated Using**
Western blot	0.1-0.5μg/ml	Human, Rat Mouse	AssaySolutio's ECL kit

AssaySolution recommends Rabbit Chemiluminescent WB Detection Kit (AKIT001B) for Western blot. *Blocking peptide can be purchased at $65. Contact us for more information