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More info
Overview
Long Name | Antibody Type | Antibody Isotype | Host | Species Reactivity | Validated Applications | Purification |
| transient receptor potential cation channel, subfamily C, member 4 | Polyclonal | IgG | Rabbit | Human | WB | Immunogen affinity purified. |
Immunogen | ||||||
| A synthetic peptide corresponding to a sequence at the C-terminus of human TRPC4(961-977aa LNLPDTVTHEDYVTTRL). | ||||||
Properties
Form | Lyophilized |
Size | 100 µg/vial |
Contents | Antibody is lyophilized with 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal and 0.05 mg NaN3. *carrier free antibody available upon request. |
Concentration | Reconstitute with 0.2 mL sterile dH2O (500 µg/ml final concentration). |
Storage | At -20 °C for 12 months, as supplied. Store reconstituted antibody at 2-8 °C for one month. For long-term storage, aliquot and store at -20 °C. Avoid repeated freezing and thawing. |
Additional Information Regarding the Antigen
Gene | TRPC4 |
Protein | Short transient receptor potential channel 4 |
Uniprot ID | Q9UBN4 |
Function | Form a receptor-activated non-selective calcium permeant cation channel. Acts as a cell-cell contact-dependent endothelial calcium entry channel. Probably operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Mediates cation entry, with an enhanced permeability to barium over calcium. May also be activated by intracellular calcium store depletion. |
Tissue Specificity | Strongly expressed in placenta. Expressed at lower levels in heart, pancreas, kidney and brain. Expressed in endothelial cells. Isoform alpha was found to be the predominant isoform. Isoform beta was not found in pancreas and brain. |
Sub-cellular localization | Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note: Enhanced insertion into the cell membrane after activation of the EGF receptor. |
Sequence Similarities | Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC4 sub-subfamily. |
Aliases | CCE1 antibody|HTRP 4 antibody|hTrp-4 antibody|HTRP4 antibody|MGC119570 antibody|MGC119571 antibody|MGC119572 antibody|MGC119573 antibody|RP11-10M8.1 antibody|Short transient receptor potential channel 4 antibody|STRPC4 antibody|Transient receptor potential 4 antibody|transient receptor potential cation channel subfamily C antibody|Transient receptor potential cation channel subfamily C member 4 antibody|transient receptor potential channel 4 antibody|TRP 4 antibody|trp related protein 4 antibody|Trp-related protein 4 antibody|TRP4 antibody|TRPC 4 antibody|TrpC4 antibody|TRPC4 protein antibody|TRPC4_HUMAN antibody |
Application Details
| Application | Concentration* | Species | Validated Using** |
| Western blot | 0.1-0.5μg/ml | Human | AssaySolutio's ECL kit |
AssaySolution recommends Rabbit Chemiluminescent WB Detection Kit (AKIT001B) for Western blot. *Blocking peptide can be purchased at $65. Contact us for more information
Anti-TRPC4 antibody, ASA-B1931, All Western blotting
All lanes: Anti-TRPC4(ASA-B1931) at 0.5ug/ml
Lane 1: COLO320 Whole Cell Lysate at 40ug
Lane 2: MCF-7 Whole Cell Lysate at 40ug
Lane 3: PANC Whole Cell Lysate at 40ug
Predicted bind size: 112KD
Observed bind size: 112KD
All lanes: Anti-TRPC4(ASA-B1931) at 0.5ug/ml
Lane 1: COLO320 Whole Cell Lysate at 40ug
Lane 2: MCF-7 Whole Cell Lysate at 40ug
Lane 3: PANC Whole Cell Lysate at 40ug
Predicted bind size: 112KD
Observed bind size: 112KD
