| Background |
Interleukin 1 alpha (IL1α) is a protein of the interleukin-1 family that in humans is encoded by the IL1A gene.In general, Interleukin 1 is responsible for the production of inflammation, as well as the promotion of fever and sepsis. IL1α inhibitors are being developed to interrupt those processes and treat diseases.IL1α is produced mainly by activated macrophages, as well as neutrophils, epithelial cells, and endothelial cells. It possesses metabolic, physiological, haematopoietic activities, and plays one of the central roles in the regulation of the immune responses. It binds to the interleukin-1 receptor. It is on the pathway that activates tumor necrosis factor-alpha.IL1α is a cytokine of the interleukin-1 family. |
