| Formulation |
ZC4H2 protein solution (0.25mg/ml) containing 20mM Tris-HCl(pH 8.5), 50% glycerol, 0.2M NaCl and 2mM DTT. |
| Purity |
Greater than 90.0% as determined by SDS-PAGE. |
| Description |
ZC4H2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 247 amino acids (1-224 a.a) and having a molecular mass of 28.6kDa.ZC4H2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. |
| Protein Background |
ZC4H2 (Zinc Finger, C4H2 Domain Containing) belongs to the zinc finger domain-containing protein family. ZC4H2 has a C-terminal zinc finger domain which is characterized by four cysteine residues and two histidine residues, and it also includes a coiled-coil region. In addition, ZC4H2 has been detected as an autoantigen in hepatocellular carcinoma patients. ZC4H2 has been identified as a potential candidate for X-linked mental retardation. Among the diseases associated with ZC4H2 are wieacker-wolf syndrome, and hepatocellular carcinoma. |
| Expression host |
Escherichia Coli. |
| Synonyms |
Zinc finger, C4H2 domain containing, HCA127, KIAA1166, WWS, Hepatocellular Carcinoma-Associated Antigen 127, WRWF, Zinc Finger C4H2 Domain-Containing Protein. |
| Reagent Appearance |
Sterile Filtered clear solution. |
| Stability |
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Amino acid sequence |
MGSSHHHHHH SSGLVPRGSH MGSMADEQEI MCKLESIKEI RNKTLQMEKI KARLKAEFEA LESEERHLKE YKQEMDLLLQ EKMAHVEELR LIHADINVME NTIKQSENDL NKLLESTRRL HDEYKPLKEH VDALRMTLGL QRLPDLCEEE EKLSLDYFEK QKAEWQTEPQ EPPIPESLAA AAAAAQQLQV ARKQDTRQTA TFRQQPPPMK ACLSCHQQIH RNAPICPLCK AKSRSRNPKK PKRKQDE. |
