| Formulation |
The RARRES1 solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.4M Urea and 10% glycerol. |
| Purity |
Greater than 90.0% as determined by SDS-PAGE. |
| Description |
RARRES1 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 275 amino acids (43-294) and having a molecular mass of 31.3 kDa. RARRES1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. |
| Protein Background |
Retinoic Acid Receptor Responder 1 (RARRES1) is a part of the TIGs (Tazarotene-induced gene) family. TIGs operate like tumor suppressor genes in human cancers and are greatly expressed in skin, hair follicles and endothelial cells plus in pancreas, spleen and intestine. TIGs are growth regulators which mediate the growth suppressive effects of retinoids and are triggered by tazarotene. |
| Expression host |
Escherichia Coli. |
| Synonyms |
Retinoic acid receptor responder protein 1 isoform 1, TIG1, Retinoic acid receptor responder protein 1, RAR-responsive protein TIG1, Tazarotene-induced gene 1 protein, RARRES1, Recombinant Human Retinoic Acid Receptor Responder 1. |
| Reagent Appearance |
Sterile Filtered colorless solution. |
| Stability |
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Amino acid sequence |
MGSSHHHHHH SSGLVPRGSH MGSPDDPGQP QDAGVPRRLL QQAARAALHF FNFRSGSPSA LRVLAEVQEG RAWINPKEGC KVHVVFSTER YNPESLLQEG EGRLGKCSAR VFFKNQKPRP TINVTCTRLI EKKKRQQEDY LLYKQMKQLK NPLEIVSIPD NHGHIDPSLR LIWDLAFLGS SYVMWEMTTQ VSHYYLAQLT SVRQWKTNDD TIDFDYTVLL HELSTQEIIP CRIHLVWYPG KPLKVKYHCQ ELQTPEEASG TEEGSAVVPT ELSNF. |
