DYRK1A Human

Data sheet

Formulation

The DYRK1A solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 10% glycerol and 0.4M Urea.

Purity

Greater than 80% as determined by SDS-PAGE.

Description

DYRK1A Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 343 amino acids (159-479a.a) and having a molecular mass of 39.4kDa. DYRK1A is fused to a 22 amino acid His-tag at N-terminus & purified by proprietary

Protein Background

Dual-Specificity Tyrosine-(Y)-Phosphorylation Regulated 1A (DYRK1A) belongs to the dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. DYRK1A includes a nuclear targeting signal sequence, a leucine zipper motif and a protein kinase d

Expression host

Escherichia Coli.

Synonyms

Dual Specificity Yak1-related kinase, Dyrk; PSK47, Dual specificity tyrosine-phosphorylation-regulated kinase 1A, Dual specificity YAK1-related kinase, Protein kinase minibrain homolog, RP86, Dyrk1a, MNBH.

Reagent Appearance

Sterile Filtered colorless solution.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.

Amino acid sequence

MGSSHHHHHH SSGLVPRGSH RSYEIDSLIG KGSFGQVVKA YDRVEQEWVA IKIIKNKKAF LNQAQIEVRL LELMNKHDTE MKYYIVHLKR HFMFRNHLCL VFEMLSYNLY DLLRNTNFRG VSLNLTRKFA QQMCTALLFL ATPELSIIHC DLKPENILLC NPKRSAIKIV DFGSSCQLGQ RIYQYIQSRF YRSPEVLLGM PYDLAIDMWS LGCILVEMHT GEPLFSGANE VD