| Clone |
P6D10AT. |
| Protein Background |
Cyclin-dependent kinase 4 combines with the protein cyclin D to form a protein complex that promotes the passage of cells through the G1 checkpoint in the cell growth cycle. This cellular activity is regulated by the protein p16 produced by p16INK4a. Normally, p16 controls cell growth by inhibiting the activity of the CDK4cyclin D complex and stopping cells at the G1 checkpoint. |
| Synonyms |
Cell division protein kinase 4, CDK4, EC 2.7.11.22, Cyclin-dependent kinase 4, PSK-J3, CMM3, CDK-4, MGC14458. |
| Type |
Mouse Anti Human Monoclonal. |
| Immunogen |
Anti-human CDK4 mAb is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with recombinant human CDK4 amino acids 1-303 purified from E. coli. |
| Ig Subclass |
Mouse IgG2b heavy chain and kappa light chain. |
| Purification Method |
CDK4 antibody was purified from mouse ascitic fluids by protein-G affinity chromatography. |
| Protein formulation |
1mg/ml containing PBS, pH-7.4, & 0.02% Sodium Azide and 10% Glycerol. |
| Storage Procedures |
For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles. |
| Stability / Shelf Life |
12 months at -20°C. 1 month at 4°C. |
