Formulation |
C9 protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 10% glycerol and 0.4M Urea. |
Purity |
Greater than 80% as determined by SDS-PAGE. |
Description |
C9 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 561 amino acids (22-559 a.a) and having a molecular mass of 63.4kDa.C9 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. |
Protein Background |
Complement Component 9 also known as C9 is the final component of the complement system. C9 plays a part in the formation of the Membrane Attack Complex (MAC). The MAC gathers on bacterial membranes to form a pore, permitting disruption of bacterial membrane organization. Component C9 deficiency is caused by mutations in this gene. Among the diseases associated with C9 are c9 deficiency, and primary amebic meningoencephalitis. |
Expression host |
Escherichia Coli. |
Synonyms |
Complement Component 9, ARMD15, C9D, Complement Component C9. |
Reagent Appearance |
Sterile Filtered clear solution. |
Stability |
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please avoid freeze thaw cycles. |
Amino acid sequence |
MGSSHHHHHH SSGLVPRGSH MGSQYTTSYD PELTESSGSA SHIDCRMSPW SEWSQCDPCL RQMFRSRSIE VFGQFNGKRC TDAVGDRRQC VPTEPCEDAE DDCGNDFQCS TGRCIKMRLR CNGDNDCGDF SDEDDCESEP RPPCRDRVVE ESELARTAGY GINILGMDPL STPFDNEFYN GLCNRDRDGN TLTYYRRPWN VASLIYETKG EKNFRTEHYE EQIEAFKSII QEKTSNFNAA ISLKFTPTET NKAEQCCEET ASSISLHGKG SFRFSYSKNE TYQLFLSYSS KKEKMFLHVK GEIHLGRFVM RNRDVVLTTT FVDDIKALPT TYEKGEYFAF LETYGTHYSS SGSLGGLYEL IYVLDKASMK RKGVELKDIK RCLGYHLDVS LAFSEISVGA EFNKDDCVKR GEGRAVNITS ENLIDDVVSL IRGGTRKYAF ELKEKLLRGT VIDVTDFVNW ASSINDAPVL ISQKLSPIYN LVPVKMKNAH LKKQNLERAI EDYINEFSVR KCHTCQNGGT VILMDGKCLC ACPFKFEGIA CEISKQKISE GLPALEFPNE K |