Interleukin-23 Human Recombinant ( IL 23 Human )

Data sheet

Formulation

IL-23 was lyophilized from a concentrated (480ug/ml) sterile solution containing 1x PBS.

Solubility

It is recommended to reconstitute the lyophilized Interleukin-23 in sterile 18M-cm H2O not less than 100ug/ml, which can then be further diluted to other aqueous solutions.

Purity

Greater than 95.0% as determined by analysis by SDS-PAGE.

Description

IL-23 Human Recombinant produced in HEK cells is a 55kDa heterodimeric protein composed of 2 disulfide-linked subunits - 19kDa (p19) and 43 kDa (p40).

Protein Background

IL23 is composed of a subunit of the heterodimeric cytokine IL23 and the p40 subunit of interleukin 12 (IL12B). Interleukin-23 (IL-23) belongs to the IL-12 family and is produced by antigen presenting cells. IL-23 using IL12RB1 and IL-23R (specific for IL

Expression host

HEK.

Synonyms

Interleukin 23 alpha subunit p19, Interleukin-12 subunit beta p40, SGRF, IL23P19, IL-23-A, interleukin-six, G-CSF related factor, JKA3 induced upon T-cell activation, interleukin 12B (natural killer cell stimulatory factor 2 cytotoxic lymphocyte maturatio

Reagent Appearance

IL-23 if supplied as a sterile filtered White lyophilized (freeze-dried) powder.

Stability

Lyophilized Interleukin-23 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution IL-23 should be stored at 4°C between 2-7 days and for future use below -18°C.Please prevent freeze-thaw cycles.

Biological Activity

The activity, as determined by the dose dependent secretion of h-IFN-g from human PBMC was found to be 2 to 20ng/ml ED50.