More info
Overview
Long Name | Antibody Type | Antibody Isotype | Host | Species Reactivity | Validated Applications | Purification |
| tumor necrosis factor receptor superfamily, member 1A | Polyclonal | IgG | Rabbit | Human | IHC-P, WB | Immunogen affinity purified. |
Immunogen | ||||||
| A synthetic peptide corresponding to a sequence in the middle region of human TNF Receptor I(195-211aa CLPQIENVKGTEDSGTT) . | ||||||
Properties
Form | Lyophilized |
Size | 100 µg/vial |
Contents | Antibody is lyophilized with 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal and 0.05 mg NaN3. *carrier free antibody available upon request. |
Concentration | Reconstitute with 0.2 mL sterile dH2O (500 µg/ml final concentration). |
Storage | At -20 °C for 12 months, as supplied. Store reconstituted antibody at 2-8 °C for one month. For long-term storage, aliquot and store at -20 °C. Avoid repeated freezing and thawing. |
Additional Information Regarding the Antigen
Gene | TNFRSF1A |
Protein | Tumor necrosis factor receptor superfamily member 1A |
Uniprot ID | P19438 |
Function | Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate- specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase. |
Tissue Specificity | |
Sub-cellular localization | Cell membrane. |
Sequence Similarities | Contains 1 death domain. |
Aliases | CD120a antibody|FPF antibody|MGC19588 antibody|p55 antibody|p55 R antibody|P55R antibody|p60 antibody|TBP 1 antibody|TBP1 antibody|TBPI antibody|TNF R antibody|TNF R I antibody|TNF R55 antibody|TNF-R1 antibody|TNF-RI antibody|TNFAR antibody|TNFR 55 antibody|TNFR 60 antibody|TNFR antibody|TNFR-I antibody|TNFR1 antibody|TNFR55 antibody|TNFR60 antibody|TNFRI antibody|TNFRSF1A antibody|TNR1A_HUMAN antibody|Tumor necrosis factor alpha receptor antibody|Tumor necrosis factor binding protein 1 antibody|Tumor necrosis factor receptor 1 antibody|Tumor necrosis factor receptor superfamily member 1A antibody|Tumor necrosis factor receptor type 1 antibody|Tumor necrosis factor receptor type I antibody|Tumor necrosis factor-binding protein 1 antibody |
Application Details
| Application | Concentration* | Species | Validated Using** |
| Western blot | 0.1-0.5μg/ml | Human | AssaySolutio's ECL kit |
| Immunohistochemistry(Paraffin-embedded Section) | 0.5-1μg/ml | Human | AssaySolutio's IHC/ICC Detection kit |
AssaySolution recommends Rabbit Chemiluminescent WB Detection Kit (AKIT001B) for Western blot, and Rabbit Peroxidase IHC/ICC Detection Kit (AKIT002B) for IHC(P). *Blocking peptide can be purchased at $65. Contact us for more information
Anti-TNF Receptor I antibody, ASA-B1886, Western blotting
Lane 1: Recombinant Human TNFR1 Protein 10ng
Lane 2: Recombinant Human TNFR1 Protein 5ng
Lane 3: Recombinant Human TNFR1 Protein 2.5ng
Lane 1: Recombinant Human TNFR1 Protein 10ng
Lane 2: Recombinant Human TNFR1 Protein 5ng
Lane 3: Recombinant Human TNFR1 Protein 2.5ng
Anti-TNF Receptor I antibody, ASA-B1886, IHC(P)
IHC(P): Human Mammary Tissue
IHC(P): Human Mammary Tissue
