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Tau Antibody (monoclonal) View larger

Tau Antibody (monoclonal)

ASA-B1836

$330.00

More info

Overview

Long Name

Antibody Type

Antibody Isotype

Host

Species Reactivity

Validated Applications

Purification 
microtubule-associated protein tau Monoclonal IgG Mouse Bovine, Human IHC-P, WB Ascites

Immunogen

Bovine microtubule-associated proteins(MAPs).

Properties

Form

 Lyophilized

Size

 100 µg/vial

Contents

 Mouse ascites fluid, 1.2% sodium acetate, 2 mg BSA, with 0.01 mg NaN3 as preservative. *carrier free antibody available upon request.

Concentration

 1.2% sodium acetate or neutral PBS. If 1ml of PBS is used, the antibody concentration will be 100 µg/ml.

Storage

 At -20 °C for 12 months, as supplied. Store reconstituted antibody at 2-8 °C for one month. For long-term storage, aliquot and store at -20 °C. Avoid repeated freezing and thawing.

Additional Information Regarding the Antigen

Gene

 MAPT

Protein

 Microtubule-associated protein tau

Uniprot ID

 Human(P10636), Mouse(P10637), Rat(P19332)

Function

 Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N- terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.

Tissue Specificity

Expressed in neurons. Isoform PNS-tau is expressed in the peripheral nervous system while the others are expressed in the central nervous system.

Sub-cellular localization

 Cytoplasm, cytosol.

Sequence Similarities

 Contains 4 Tau/MAP repeats.

Aliases

 DDPAC|MAPTL|PHF-tau|FLJ31424|FTDP-17|MGC138549|MSTD|MTBT1|MTBT2|PPND|TAU|G protein beta1/gamma2 subunit-interacting factor 1|microtubule-associated protein tau, isoform 4|Neurofibrillary tangle protein|Paired helical filament-tau

Application Details

Application Concentration* Species Validated Using**
Western blot0.5-1μg/mlHuman, bovineAssaySolutio's ECL kit
Immunohistochemistry(Paraffin-embedded Section)1-2μg/mlHuman, bovineAssaySolutio's IHC/ICC Detection kit

AssaySolution recommends Mouse Chemiluminescent WB Detection Kit (AKIT003B) for Western blot, and Mouse Peroxidase IHC/ICC Detection Kit (AKIT004B) for IHC(P). *Blocking peptide can be purchased at $65. Contact us for more information
Anti-Tau antibody (monoclonal), ASA-B1836, Western blotting
Lane 1: Rat Brain Tissue Lysate
Lane 2: Rat Brain Tissue Lysate
Lane 3: Mouse Brain Tissue Lysate
Lane 4: Mouse Brain Tissue Lysate

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