ASA-B1726
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Smad1 Antibody
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Long Name | Antibody Type | Antibody Isotype | Host | Species Reactivity | Validated Applications | Purification |
SMAD family member 1 | Polyclonal | IgG | Rabbit | Human, Mouse, Rat | IHC-P, ICC, WB | Immunogen affinity purified. |
Immunogen | ||||||
A synthetic peptide corresponding to a sequence at the C-terminus of mouse Smad1(253-267aa AEISRGDVQAVAYEE), different from the related rat sequence by one amino acid, and different from the related human sequence by two amino acids. |
Form | Lyophilized |
Size | 100 µg/vial |
Contents | Antibody is lyophilized with 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal and 0.05 mg NaN3. *carrier free antibody available upon request. |
Concentration | Reconstitute with 0.2 mL sterile dH2O (500 µg/ml final concentration). |
Storage | At -20 °C for 12 months, as supplied. Store reconstituted antibody at 2-8 °C for one month. For long-term storage, aliquot and store at -20 °C. Avoid repeated freezing and thawing. |
Gene | SMAD1 |
Protein | Mothers against decapentaplegic homolog 1 |
Uniprot ID | P70340 |
Function | Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor-regulated SMAD (R-SMAD) (By similarity). May play a role in the initiation and maintenance of spermatogenesis. SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1 (By similarity). May act synergistically with SMAD4 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression (PubMed:15329343). |
Tissue Specificity | Ubiquitous. |
Sub-cellular localization | Cytoplasm . Nucleus . Note: In the cytoplasm in the absence of ligand. Migration to the nucleus when complexed with SMAD4. Colocalizes with LEMD3 at the nucleus inner membrane (By similarity). |
Sequence Similarities | Belongs to the dwarfin/SMAD family. |
Aliases | BSP-1 antibody|BSP1 antibody|Dwarfin A antibody|DwfA antibody|HsMAD1 antibody|JV4 1 antibody|JV4-1 antibody|JV41 antibody|MAD homolog 1 antibody|MAD mothers against decapentaplegic homolog 1 antibody|Mad related protein 1 antibody|Mad-related protein 1 antibody|MADH1 antibody|Madr 1 antibody|MADR1 antibody|Mothers against decapentaplegic homolog 1 antibody|Mothers against DPP homolog 1 antibody|SMA- AND MAD-RELATED PROTEIN 1 antibody|SMAD 1 antibody|SMAD family member 1 antibody|SMAD mothers against DPP homolog 1 antibody|SMAD mothers against DPP homolog 1 Drosophila antibody|Smad1 antibody|SMAD1_HUMAN antibody|Spinal muscular atrophy distal with upper limb predominance antibody|TGF beta signaling protein 1 antibody|Transforming growth factor beta signaling protein 1 antibody|Transforming growth factor-beta-signaling protein 1 antibody |
Application | Concentration* | Species | Validated Using** |
Western blot | 0.1-0.5μg/ml | Human Mouse, Rat | AssaySolutio's ECL kit |
Immunohistochemistry(Paraffin-embedded Section) | 0.5-1μg/ml | Human, Rat Mouse | AssaySolutio's IHC/ICC Detection kit |
Immunocytochemistry | 0.5-1μg/ml | Human Mouse | AssaySolutio's IHC/ICC Detection kit |