ASA-B1414
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Nrf2 Antibody
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Long Name | Antibody Type | Antibody Isotype | Host | Species Reactivity | Validated Applications | Purification |
nuclear factor, erythroid 2-like 2 | Polyclonal | IgG | Rabbit | Human, Mouse, Rat | IHC-P, WB | Immunogen affinity purified. |
Immunogen | ||||||
E.coli-derived human Nrf2 recombinant protein (Position: Q14-D178). Human Nrf2 shares 79% and 82% amino acid (aa) sequence identity with mouse and rat Nrf2, respectively. |
Form | Lyophilized |
Size | 100 µg/vial |
Contents | Antibody is lyophilized with 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg NaN3. *carrier free antibody available upon request. |
Concentration | Reconstitute with 0.2 mL sterile dH2O (500 µg/ml final concentration). |
Storage | At -20 °C for 12 months, as supplied. Store reconstituted antibody at 2-8 °C for one month. For long-term storage, aliquot and store at -20 °C. Avoid repeated freezing and thawing. |
Gene | NFE2L2 |
Protein | Nuclear factor erythroid 2-related factor 2 |
Uniprot ID | Q16236 |
Function | Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region. |
Tissue Specificity | Widely expressed. Highest expression in adult muscle, kidney, lung, liver and in fetal muscle. |
Sub-cellular localization | Cytoplasm, cytosol. Nucleus. Note: Cytosolic under unstressed conditions, translocates into the nucleus upon induction by electrophilic agents. |
Sequence Similarities | Belongs to the bZIP family. CNC subfamily. |
Aliases | erythroid derived 2 antibody|HEBP1 antibody|NF E2 related factor 2 antibody|NF-E2-related factor 2 antibody|NF2L2_HUMAN antibody|NFE2 related factor 2 antibody|NFE2-related factor 2 antibody|NFE2L2 antibody|Nrf 2 antibody|NRF2 antibody|Nuclear factor antibody|nuclear factor erythroid 2 like 2 antibody|Nuclear factor erythroid 2 related factor 2 antibody|Nuclear factor erythroid 2-related factor 2 antibody|Nuclear factor erythroid derived 2 like 2 antibody |
Application | Concentration* | Species | Validated Using** |
Western blot | 0.1-0.5μg/ml | Human, Mouse, Rat | AssaySolutio's ECL kit |
Immunohistochemistry(Paraffin-embedded Section) | 0.5-1μg/ml | Human | AssaySolutio's IHC/ICC Detection kit |