Cytochrome P450 2D6 Antibody View larger

Cytochrome P450 2D6 Antibody

ASA-B0562

$330.00

More info

Overview

Long Name

Antibody Type

Antibody Isotype

Host

Species Reactivity

Validated Applications

Purification 

cytochrome P450, family 2, subfamily D, polypeptide 6 Polyclonal IgG Rabbit Mouse, Rat IHC-P, WB Immunogen affinity purified.

Immunogen

A synthetic peptide corresponding to a sequence in the middle region of mouse Cytochrome P450 2D6(194-214aa FACRFEYNDPRFIRLLDLLKD), identical to the related rat sequence.

Properties

Form

Lyophilized

Size

100 µg/vial

Contents

Antibody is lyophilized with 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal and 0.05 mg NaN3. *carrier free antibody available upon request.

Concentration

Reconstitute with 0.2 mL sterile dH2O (500 µg/ml final concentration).

Storage

At -20 °C for 12 months, as supplied. Store reconstituted antibody at 2-8 °C for one month. For long-term storage, aliquot and store at -20 °C. Avoid repeated freezing and thawing.

Additional Information Regarding the Antigen

Gene

CYP2D6

Protein

Cytochrome P450 2D6

Uniprot ID

P10635

Function

Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.

Tissue Specificity

Sub-cellular localization

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Sequence Similarities

Belongs to the cytochrome P450 family.

Aliases

CPD6 antibody|CYP2D antibody|CYP2D6 antibody|CYP2D7AP antibody|CYP2D7BP antibody|CYP2D7P2 antibody|CYP2D8P2 antibody|CYP2DL1 antibody|CYPIID6 antibody|Cytochrome P450 DB1 antibody|Cytochrome P450 family 2 subfamily D polypeptide 6 antibody|Debrisoquine 4 hydroxylase antibody|EC 1.14.14.1 antibody|Flavoprotein linked monooxygenase antibody|MGC120389 antibody|MGC120390 antibody|Microsomal monooxygenase antibody|P450 DB1 antibody|P450C2D antibody|P450DB1 antibody|Xenobiotic monooxygenase antibody

Application Details

Application Concentration* Species Validated Using**
Western blot 0.1-0.5μg/ml Rat MouseAssaySolutio's ECL kit
Immunohistochemistry(Paraffin-embedded Section) 0.5-1μg/ml Rat MouseAssaySolutio's IHC/ICC Detection kit

AssaySolution recommends Rabbit Chemiluminescent WB Detection Kit (AKIT001B) for Western blot, and Rabbit Peroxidase IHC/ICC Detection Kit (AKIT002B) for IHC(P). *Blocking peptide can be purchased at $65. Contact us for more information
Anti-Cytochrome P450 2D6 antibody, ASA-B0562, Western blotting
Lane 1: Rat Liver Tissue Lysate
Lane 2: Rat Kidney Tissue Lysate
Lane 3: Rat Brain Tissue Lysate

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