ASA-B0388
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CD46 Antibody
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Long Name | Antibody Type | Antibody Isotype | Host | Species Reactivity | Validated Applications | Purification |
CD46 molecule, complement regulatory protein | Polyclonal | IgG | Rabbit | Human | IHC-P, WB | Immunogen affinity purified. |
Immunogen | ||||||
A synthetic peptide corresponding to a sequence at the C-terminus of human CD46 (366-392aa YRYLQRRKKKGTYLTDETHREVKFTSL). |
Form | Lyophilized |
Size | 100 µg/vial |
Contents | Antibody is lyophilized with 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg NaN3. *carrier free antibody available upon request. |
Concentration | Reconstitute with 0.2 mL sterile dH2O (500 µg/ml final concentration). |
Storage | At -20 °C for 12 months, as supplied. Store reconstituted antibody at 2-8 °C for one month. For long-term storage, aliquot and store at -20 °C. Avoid repeated freezing and thawing. |
Gene | CD46 |
Protein | Membrane cofactor protein |
Uniprot ID | P15529 |
Function | Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement- mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T- cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46. |
Tissue Specificity | Expressed by all cells except erythrocytes. |
Sub-cellular localization | Cytoplasmic vesicle, secretory vesicle, acrosome inner membrane. |
Sequence Similarities | Contains 4 Sushi (CCP/SCR) domains. |
Aliases | AHUS2 antibody|Antigen defined by monoclonal antibody| TRA 2 10 antibody| Antigen identified by monoclonal antibody| TRA 2 10 antibody|CD46 antibody| CD46 antigen antibody|CD46 antigen complement regulatory protein antibody| CD46 molecule antibody|CD46 molecule complement regulatory protein antibody|Complement membrane cofactor protein antibody|MCP antibody| MCP_HUMAN antibody|Measles virus receptor antibody|membrane cofactor protein (CD46, trophoblast-lymphocyte cross-reactive antigen) antibody| Membrane cofactor protein antibody| MGC26544 antibody|MIC10 antibody|TLX antibody|TRA2.10 antibody|Trophoblast leucocyte common antigen antibody| Trophoblast leukocyte common antigen antibody|Trophoblast lymphocyte cross reactive antigen antibody |
Application | Concentration* | Species | Validated Using** |
Western blot | 0.1-0.5μg/ml | Human | AssaySolutio's ECL kit |
Immunohistochemistry(Paraffin-embedded Section) | 0.5-1μg/ml | Human | AssaySolutio's IHC/ICC Detection kit |