ASA-B0333
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CCR4 Antibody
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Long Name | Antibody Type | Antibody Isotype | Host | Species Reactivity | Validated Applications | Purification |
chemokine(C-C motif) receptor 4 | Polyclonal | IgG | Rabbit | Human | IHC-P, WB | Immunogen affinity purified. |
Immunogen | ||||||
A synthetic peptide corresponding to a sequence at the C-terminus of human CCR4(346-360aa SYTQSTMDHDLHDAL). |
Form | Lyophilized |
Size | 100 µg/vial |
Contents | Antibody is lyophilized with 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal and 0.05 mg NaN3. *carrier free antibody available upon request. |
Concentration | Reconstitute with 0.2 mL sterile dH2O (500 µg/ml final concentration). |
Storage | At -20 °C for 12 months, as supplied. Store reconstituted antibody at 2-8 °C for one month. For long-term storage, aliquot and store at -20 °C. Avoid repeated freezing and thawing. |
Gene | CCR4 |
Protein | C-C chemokine receptor type 4(C-C CKR-4/CC-CKR-4/CCR-4/CCR4) |
Uniprot ID | P51679 |
Function | High affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival. |
Tissue Specificity | Predominantly expressed in the thymus, in peripheral blood leukocytes, including T-cells, mostly CD4+ cells, and basophils, and in platelets; at lower levels, in the spleen and in monocytes. Detected also in macrophages, IL-2-activated natural killer cells and skin-homing memory T-cells, mostly the ones expressing the cutaneous lymphocyte antigen (CLA). Expressed in brain microvascular and coronary artery endothelial cells. |
Sub-cellular localization | Cell membrane; Multi-pass membrane protein. |
Sequence Similarities | Belongs to the G-protein coupled receptor 1 family. |
Aliases | C C chemokine receptor type 4 antibody|C C CKR 4 antibody|C-C chemokine receptor type 4 antibody|C-C CKR-4 antibody|CC CKR 4 antibody|CC-CKR-4 antibody|CCR 4 antibody|CCR-4 antibody|CCR4 antibody|CCR4_HUMAN antibody|CD194 antibody|Chemokine(CC motif) receptor 4 antibody|chemokine C C motif receptor 4 antibody|ChemR13 antibody|CKR4 antibody|CMKBR 4 antibody|CMKBR4 antibody|HGCN 14099 antibody|K5 5 antibody|K5-5 antibody|MGC88293 antibody |
Application | Concentration* | Species | Validated Using** |
Western blot | 0.1-0.5μg/ml | Human | AssaySolutio's ECL kit |
Immunohistochemistry(Paraffin-embedded Section) | 0.5-1μg/ml | Human | AssaySolutio's IHC/ICC Detection kit |