Androgen Receptor Antibody View larger

Androgen Receptor Antibody

ASA-B0081

$330.00

More info

Overview

Long Name

Antibody Type

Antibody Isotype

Host

Species Reactivity

Validated Applications

Purification 

androgen receptorPolyclonalIgGRabbitHuman, Mouse, RatIHC-P, ICC, WBImmunogen affinity purified.

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human Androgen Receptor(822-838aa LKNQKFFDELRMNYIKE), identical to the related rat and mouse sequences.

Properties

Form

Lyophilized

Size

100 µg/vial

Contents

Antibody is lyophilized with 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal and 0.05 mg NaN3. *carrier free antibody available upon request.

Concentration

Reconstitute with 0.2 mL sterile dH2O (500 µg/ml final concentration).

Storage

At -20 °C for 12 months, as supplied. Store reconstituted antibody at 2-8 °C for one month. For long-term storage, aliquot and store at -20 °C. Avoid repeated freezing and thawing.

Additional Information Regarding the Antigen

Gene

AR

Protein

Androgen receptor

Uniprot ID

P10275

Function

Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.

Tissue Specificity

Isoform 2 is mainly expressed in heart and skeletal muscle.

Sub-cellular localization

Nucleus. Cytoplasm. Note: Predominantly cytoplasmic in unligated form but translocates to the nucleus upon ligand-binding. Can also translocate to the nucleus in unligated form in the presence of GNB2L1.

Sequence Similarities

Belongs to the nuclear hormone receptor family. NR3 subfamily.

Aliases

AIS antibody|ANDR_HUMAN antibody|Androgen receptor(dihydrotestosterone receptor; testicular feminization; spinal and bulbar muscular atrophy; Kennedy disease) antibody|Androgen receptor antibody|AR antibody|DHTR antibody|Dihydro Testosterone Receptor antibody|Dihydrotestosterone receptor antibody|HUMARA antibody|HYSP1 antibody|KD antibody|NR3C4 antibody|Nuclear receptor subfamily 3 group C member 4 antibody|SBMA antibody|SMAX1 antibody|Spinal and bulbar muscular atrophy antibody|TFM antibody

Application Details

ApplicationConcentration*SpeciesValidated Using**
Western blot0.1-0.5μg/mlHuman, Rat MouseAssaySolutio's ECL kit
Immunohistochemistry(Paraffin-embedded Section)0.5-1μg/mlHuman, Rat MouseAssaySolutio's IHC/ICC Detection kit
Immunocytochemistry0.5-1μg/mlHuman MouseAssaySolutio's IHC/ICC Detection kit


AssaySolution recommends Rabbit Chemiluminescent WB Detection Kit (AKIT001B) for Western blot, and Rabbit Peroxidase IHC/ICC Detection Kit (AKIT002B) for IHC(P) and ICC. *Blocking peptide can be purchased at $65. Contact us for more information

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