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Overview
Long Name | Antibody Type | Antibody Isotype | Host | Species Reactivity | Validated Applications | Purification |
| aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 | Polyclonal | IgG | Rabbit | Human, Mouse, Rat | IHC-P, WB | Immunogen affinity purified. |
Immunogen | ||||||
| A synthetic peptide corresponding to a sequence in the middle region of human AIMP2/p38(298-320aa NVQRWMRSCENLAPFNTALKLLK), different from the related rat and mouse sequences by three amino acids. | ||||||
Properties
Form | Lyophilized |
Size | 100 µg/vial |
Contents | Antibody is lyophilized with 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal and 0.05 mg NaN3. *carrier free antibody available upon request. |
Concentration | Reconstitute with 0.2 mL sterile dH2O (500 µg/ml final concentration). |
Storage | At -20 °C for 12 months, as supplied. Store reconstituted antibody at 2-8 °C for one month. For long-term storage, aliquot and store at -20 °C. Avoid repeated freezing and thawing. |
Additional Information Regarding the Antigen
Gene | AIMP2 |
Protein | Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 |
Uniprot ID | Q13155 |
Function | Required for assembly and stability of the aminoacyl- tRNA synthase complex. Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down- regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor. |
Tissue Specificity | |
Sub-cellular localization | Cytoplasm, cytosol . Nucleus . Note: Following DNA damage, dissociates from the aminoacyl-tRNA synthase complex and translocates from the cytoplasm to the nucleus. |
Sequence Similarities | Contains 1 GST C-terminal domain. |
Aliases | Aimp2 antibody|AIMP2_HUMAN antibody|Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 antibody|Aminoacyl tRNA synthetase complex interacting multifunctional protein 2 antibody|ARS interacting multi functional protein 2 antibody|JTV 1 antibody|JTV 1 protein antibody|JTV1 antibody|Multisynthase complex auxiliary component p38 antibody|Multisynthetase complex auxiliary component p38 antibody|P38 antibody|PRO0992 antibody|Protein JTV 1 antibody|Protein JTV-1 antibody|tRNA SYNTHETASE COFACTOR p38 antibody |
Application Details
| Application | Concentration* | Species | Validated Using** |
| Western blot | 0.1-0.5μg/ml | Human, Rat Mouse | AssaySolutio's ECL kit |
| Immunohistochemistry(Paraffin-embedded Section) | 0.5-1μg/ml | Human, Rat Mouse | AssaySolutio's IHC/ICC Detection kit |
AssaySolution recommends Rabbit Chemiluminescent WB Detection Kit (AKIT001B) for Western blot, and Rabbit Peroxidase IHC/ICC Detection Kit (AKIT002B) for IHC(P). *Blocking peptide can be purchased at $65. Contact us for more information
Anti-AIMP2/p38 antibody, ASA-B0057, Western blotting
Lane 1: Rat Liver Tissue Lysate
Lane 2: Rat Lung Tissue Lysate
Lane 3: Rat Kidney Tissue Lysate
Lane 4: Rat Brain Tissue Lysate
Lane 5: Marker
Lane 6: JURKAT Cell Lysate
Lane 7: CEM Cell Lysate
Lane 8: HUT Cell Lysate
Lane 9: U93T Cell Lysate
Lane 10: U93T Cell Lysate
Lane 1: Rat Liver Tissue Lysate
Lane 2: Rat Lung Tissue Lysate
Lane 3: Rat Kidney Tissue Lysate
Lane 4: Rat Brain Tissue Lysate
Lane 5: Marker
Lane 6: JURKAT Cell Lysate
Lane 7: CEM Cell Lysate
Lane 8: HUT Cell Lysate
Lane 9: U93T Cell Lysate
Lane 10: U93T Cell Lysate
Anti-AIMP2/p38 antibody, ASA-B0057, IHC (P)
Human Rectal Cancer Tissue