Human TEM7 / PLXDC1 ELISA Kit

Tumor endothelial marker 7 (TEM7), also known as plexin domain-containing 1 (PLXDC1), is an important tumor marker which belongs to the plexin family. TEM7 plays a critical role in endothelial cell capillary morphogenesis.  TEM7 protein is overexpressed in the blood vessels of human solid tumors such as colon, lung, and esophageal cancers. This protein is expressed as a complex pattern of transcripts derived by alternative splicing with potentially different activities and biological functions. These isoforms are intracellular (TEM7-I), secreted (TEM7-S), or on the cell surface membrane (TEM7-M) of the endothelial cells of tumors. High expression of TEM7 is also associated with metastasis and poor survival of patients with osteogenic sarcoma.