Human Fc gamma RIIB ( CD32b) ELISA Kit

Receptors that recognize the Fc portion of IgG are divided into three groups designated Fc gamma RI, RII, and RIII, also known respectively as CD64, CD32, and CD16.CD32 is a low affinity receptor for IgG. The activating isoform, CD32A, is expressed on monocytes, neutrophils, platelets and dendritic cells. Ligation of this receptor leads to cell activation. The inhibitory CD32B is expressed on B cells and myeloid dendritic cells.Ligation of CD32B on B cells downregulates antibody production and may promote apoptosis. Co-ligation of CD32B on dendritic cells inhibits maturation and blocks cell activation. CD32B may also be a target for monoclonal antibody therapy for malignancies.