Human Proteinase anti-neutrophil cytoplasmic antibody (PR3-ANCA) ELISA Kit

Proteinase 3, also known as PRTN3, is a 29 kD protein found in the primary granules of neutrophils and monocytes. PRTN3 is a serine protease with broad proteolytic activity against a variety of extracellular matrix proteins. Polymorphonuclear leukocyte serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro) and causes emphysema when administered by tracheal insufflation to hamsters. Its exact role in the function of the neutrophil is unknown, but, in human neutrophils, proteinase 3 contributes to the proteolytic generation of antimicrobial peptides. It is also the epitope of anti-neutrophil cytoplasmic antibodies (ANCAs) of the c-ANCA (cytoplasmic subtype) class, a type of antibody frequently found in the disease granulomatosis with polyangiitis.