Human Tetranectin/CLEC3B ELISA Kit

CLEC3B (C-type lectin domain family 3 member B), also known as Tetranectin, is a 17 kDa protein belonging to the C-type lectin superfamily. CLEC3B is secreted by endocrine, epithelial, endothelial, and mesenchymal cells including several hematopoietic cell types. CLEC3B shows binding selectivity for heparan sulfate, fucoidan, and chondroitin sulfates A, B, and C. CLEC3B binds the Kringle domain-containing proteins Plasminogen, tPA, and HGF, and it enhances the tPA-mediated activation of Plasminogen. It also reduces the ability of Angiostatin (a Plasminogen fragment) to inhibit vascular endothelial cell proliferation. CLEC3B is upregulated in stromal cells surrounding various tumors but not in the tumor cells themselves. The serum or saliva Tetranectin may serve as a potential biomarker for metastatic oral squamous cell carcinoma (OSCC).