More info
Product name | Recombinant Human GDF-11 Protein |
Size | 5 µg /20 µg/100 µg |
Purity | Greater than 98% by SDS-PAGE gel and HPLC analysis |
Protein Species | Human |
Source | E. coli |
Sequence | NLGLDCDEHS SESRCCRYPL TVDFEAFGWD WIIAPKRYKA NYCSGQCEYM FMQKYPHTHL VQQANPRGSA GPCCTPTKMS PINMLYFNDK QQIIYGKIPG MVVDRCGCS |
Appearance Bioactivity | Lyophilized powder The ED50 was determined by its ability to inhibit induced alkaline phosphatase production by ATDC-5 chondrogenic cells. The expected ED50 for this effect is 0.08-0.10 µg/ml |
Storage | Store at 4°C (short term, <1 week), frozen at -20°C or below for long term, avoid repeated freeze/thaw cycles |
Remark | GDF11 (Growth differentiation factor 11), also known as bone morphogenetic protein 11 (BMP-11), is a member of transforming growth factor beta superfamily (TGFβ). The mature 109 amino acid (aa) GDF11, derived from the full-length 407 aa GDF11 precursor protein, contains a canonical 7cysteine motif of the TGFβ superfamily members. GDF11 plays a key role in regulating embryonic development. This recombinant Human GDF-11 is a 25.0 kDa disulfide-linked homodimer containing two 109 amino acid polypeptide chains. This protein is expressed in E. coli and is purified by proprietary chromatographic techniques. |