Human Complement Factor B

Background:

Complement factor B is a glycosylated protein composed of a single 93,000 Da polypeptide chain. It is found in plasma and is required for the activation of the alternative pathway of complement. In the presence of Mg⁺⁺ , factor B binds to C3b and the C3b, B complex can be activated by factor D, a serine protease that circulates as an active trypsin-like serine protease.

Storage:

-70 C or below. Avoid freeze/thaw

Source:

Normal human serum

Activity:

Purity:

>90% versus normal human serum standard 

>90% by SDS-PAGE

Molecular Weight:

Size:

93,000 Da (single chain)

250 µg/vial

Concentration:

1.0 mg/mL

Buffer:

10 mM sodium phosphate, 145 mM NaCl, pH 7.3

Preservative:

None, 0.22 µm filtered