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Background: | Native human C8 is a naturally glycosylated protein composed of three polypeptide chains. The alpha chain (64,000 Da) and the gamma chain (22,000 Da) are disulfide linked. The beta chain (64,000 Da) is non-covalently bound to the a-g complex. C8 is essential for formation of the membrane attack complex (MAC) and is activated non-proteolytically by binding to newly-formed C5b, C6, C7 complexes on the cell membrane. |
Storage: | -70℃ or below. Avoid freeze/thaw |
Source: | Normal human serum |
Activity: Purity: | >90% versus normal human serum standard >90% by SDS-PAGE |
Molecular Weight: Size: | 151,000 Da (3 chains) 250 µg/vial |
Concentration: | 1.0 mg/mL |
Buffer: | 10 mM sodium phosphate, 145 mM NaCl, pH 7.3 |
Preservative: | None, 0.22 µm filtered |