More info
Background: | C5b, 6 is a product of complement activation of C5 and an intermediate in the formation of the C5b-9 membrane attack complex (MAC) of complement. Normally, the C5b, 6 complex remains bound to the C3/C5 convertase until it binds a single C7 molecule. However, in the absence of the C7 protein, C5b, 6 is released into the fluid phase. C5b, 6 is a very stable complex. During complement activation, some C5b, 6 diffuses away from the target cell and may, after combining with C7, enter the membrane of a nearby cell. This is called bystander lysis or “reactive lysis†and can be a significant source of pathology. |
Storage: | -70℃ or below. Avoid freeze/thaw |
Source: | Normal human serum |
Activity: Purity: | >10,000 Units/mg for lysis of sheep erythrocytes >90% by SDS-PAGE |
Molecular Weight: Size: | 285,000 Da (3 chains) 50 µg/vial |
Concentration: | 0.2 mg/mL |
Buffer: | 10 mM HEPES, 120 mM NaCl, pH 7.2 |
Preservative: | None, 0.22 µm filtered |