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Background: | C4b binding protein (C4BP) regulates complement activation of the classical and lectin pathways. It binds to C4b and accelerates the dissociation of C2a from the C3/C5 convertase C4b, C2a. This inactivates the central enzyme of both pathways. It also functions as a cofactor allowing factor I to cleave and permanently inactivate C4b. |
Storage: | -70℃ or below. Avoid freeze/thaw. |
Source: | Normal human serum |
Purity: | >90% by SDS-PAGE |
Molecular Weight: Size: | 540,000 Da (8 chains) 250 µg/vial |
Concentration: | 1.0 mg/mL |
Buffer: | 10 mM sodium phosphate, 145 mM NaCl, pH 7.2 |
Preservative: | None, 0.22 µm filtered |