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Bax Mouse Recombinant ( Bax Mouse )
DescriptionBax Mouse Recombinant amino acid 38-171 produced in E.Coli is a single, non-glycosylated polypeptide chain. The Mouse Bax is purified by proprietary chromatographic techniques.SourceEscherichia Coli.Physical AppearanceSterile Filtered
Data sheet
| Formulation | The protein contains 10mM Tris-HCL pH-8, 1mM EDTA and 250mM NaCl. |
| Purity | Greater than 95.0% as determined by(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE. |
| Description | Bax Mouse Recombinant amino acid 38-171 produced in E.Coli is a single, non-glycosylated polypeptide chain. The Mouse Bax is purified by proprietary chromatographic techniques. |
| Protein Background | Bcl-2associated X protein (Bax) belongs to the Bcl-2 protein family. Bax is a pro-apoptotic Bcl-2 protein containing BH1, BH2 and BH3 domains. Bax accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor bcl2 or its adenovirus homolog e1b 19k protein. Bax induces the release of cytochrome c, activation of casp3, and thereby apoptosis. Bax is expressed in a wide variety of tissues, with highest levels in the testis and ovary. Tumor suppressor protein p53 upregulates the expression of BAX. Bax has been shown to be involved in p53-mediated apoptosis. |
| Expression host | Escherichia Coli. |
| Synonyms | Apoptosis regulator BAX membrane isoform alpha, Bax, Bcl2-associated X protein. |
| Reagent Appearance | Sterile Filtered colorless solution. |
| Stability | Mouse Bax although stable at 12°C for 1 week, should be stored desiccated below -18°C. Please prevent freeze-thaw cycles. |
| References | 1.Title:Bax Regulates Production of Superoxide in Both Apoptotic and Nonapoptotic Neurons: Role of Caspases.Publication:The Journal of Neuroscience, 1 December 2010, 30(48): 16114-16127; doi: 10.1523/?JNEUROSCI.2862-10.2010 The Journal of Neuroscience, 1 December 2010, 30(48): 16114-16127; doi: 10.1523/?JNEUROSCI.2862-10.2010 Link:http://www.jneurosci.org/content/30/48/16114.full.pdf2.Title:Interaction of Insulin-like Growth Factor-binding Protein-3 and BAX in Mitochondria Promotes Male Germ Cell ApoptosisPublication:First Published on November 3, 2009, doi: 10.1074/jbc.M109.046847 January 15, 2010 The Journal of Biological Chemistry, 285, 1726-1732. Link:http://www.jbc.org/content/285/3/1726.full |