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Rat C-Telopeptide Of Type II Callagen CTX-II ELISA Kit
BG-RAT10728
Rat C-Telopeptide Of Type II Callagen ELISA KitFor research use only. Not for use in diagnostic procedures.For general protocol and instruction, please click the following links:Quantitative Elisa Kit InstructionSandwich ELISA kit general instruction
Data sheet
| Background | Osteoarthritis (OA) is one of the most common bone and joint aging diseases; it can cause joint pain and disability. Approximately 9.29% of the US population is diagnosed with symptomatic knee OA by 60 years of age. However, the etiology and pathogenesis of OA are still unclear and it is still an incurable disease. There are no sensitive diagnostic techniques other than classical radiography; accordingly, OA is often not detected until the middle or end stage. Owing to the absence of disease-modifying treatments, joint replacement is the only effective treatment for end-stage OA; other treatments cannot effectively alleviate pain or improve joint function. The earlier OA is diagnosed and treated, the better the prognosis. Therefore, there is an urgent need to develop techniques that are more effective than radiography in clinical practice. Some structural molecules and fragments derived from bone, articular cartilage, and the synovium, all of which are affected by OA, are candidate OA biomarkers. Cartilage oligomeric matrix protein (COMP) and crosslinked C-telopeptides of type II collagen (CTX-II, EKGPDPLQYMRA) are two biochemical markers; they are degradation products of joint tissues, especially the cartilage extracellular matrix, and can potentially predict the destruction of articular cartilage in OA. However, many studies of early OA diagnosis have only measured one of these two biomarkers at a single time point during the pathological process of OA. |
| Assay Type | Competitive ELISA |
| Kit Type | Colorimetric |
| Assay Time | 2 hours |
| Sample Type | Urine, Serum, Plasma |
| Assay Range | 0.97 - 1000 ng/ml |
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Rat C-Telopeptide Of Type II Callagen ELISA Kit
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