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Polyclonal Anti-SSTR2

FM-A10751

$320.00

Data sheet

Size 100ug/vial
Storage At -20C for one year. After reconstitution, at 4C for one month.
Form lyophilized
Ig type rabbit IgG
Immunogen/Antigen A synthetic peptide corresponding to a sequence in the middle
Reconstitution 0.2ml of distilled water will yield a concentration of 500μg/ml.

More info

Background
SSTR2 (Somatostatin receptor type 2) is a protein that in humans is encoded by the SSTR2 gene. Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR2 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in cerebrum and kidney. Stable SSTR2 transfection of human pancreatic cells, which do not endogenously express SSTR2, inhibits cell proliferation, tumorigenicity, and metastasis. These effects occur as a consequence of an autocrine SSTR2-dependent loop, whereby SSTR2 induces expression of its own ligand, somatostatin.SSTR2 mRNA was variably expressed in all neuroblastoma tumors with a relevant reduction in the more advanced stage.

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