| Specificity |
reactive with Human Total Akt2, reactivity with other related proteins not observed |
| Assay Range |
422-27000pg/ml |
| Sensitivity |
40.5 pg/ml |
| Size |
96 Tests |
| Storage |
2-8℃ |
| Background |
RAC-beta serine/threonine-protein kinase is an enzyme that in humans is encoded by the AKT2 gene.This gene is a putative oncogene encoding a protein belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2-like) domains. The gene was shown to be amplified and overexpressed in 2 of 8 ovarian carcinoma cell lines and 2 of 15 primary ovarian tumors. Overexpression contributes to the malignant phenotype of a subset of human ductal pancreatic cancers. The encoded protein is a general protein kinase capable of phosphorylating several known proteins. Mice lacking Akt2 have a normal body mass, but display a profound diabetic phenotype, indicating that Akt2 plays a key role in signal transduction downstream of the insulin receptor. Mice lacking Akt2 show worse outcome in breast cancer initaited by the large T antigen as well as the neu oncogene. |
| Sample type |
serum, plasma, cell culture supernatant |
| Assay duration |
4 hours |
| Assay format |
Sandwich |
| Alternative Name of Analyte |
AKT2；HIHGHH；PKBB；PKBBETA；PRKBB；RAC-BETA |
