NS-E10226
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Human RRM2B ELISA Kit
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Assay Range | 47 - 3000 pg/ml |
Ribonucleoside reductase subunit M2B (also known as RRM2B or p53R2) is an enzyme belonging to the iron- dependent ribonucleotide reductase (RNR) enzyme family, which is essential for DNA synthesis. It is widely expressed at a high level in skeletal muscle and at a weak level in thymus. RRM2B is also expressed in epithelial dysplasias and squamous cell carcinoma. This protein plays a pivotal role in cell survival by repairing damaged DNA in a p53/TP53-dependent manner. It translocates from cytoplasm to nucleus in response to DNA damage. Mutations in RRM2B gene have been shown to cause progressive external ophthalmoplegia. Increased expression of RRM2B has been correlated with gemcitabine resistance in human cholangiocarcinoma cells and may be predictive of lack of clinical benefit from gemcitabine for human cancers.