Human SCGN / Secretagogin ELISA Kit

Secretagogin, also known as SCGN, is a secreted calcium-binding protein, which is found in the cytoplasm. It is thought to be involved in potassiumchloride-stimulated calcium flux and cellproliferation. SCGN is expressed at high levels in the pancreatic islets of Langerhans and to a much lesser extent in the gastrointestinal tract (stomach, small intestine and colon), the adrenal medulla and cortex and the thyroid C-cells. In the brain, the expression is restricted to distinct subtypes of neurons with highest expression in the molecular layer of the cerebellum (stellate and basket cells), in the anterior part of the pituitary gland, in the thalamus, in the hypothalamus and in a subgroup of neocortical neurons. SCGN plays an important role in the release of the stress hormone CRH and which only then enables stress processes in the brain and SCGN is detectable in human serum after ischemic neuronal damage.