Human Coagulation Factor IX/FIX/F9 ELISA Kit

Factor IX (or Christmas factor) is one of the serine proteases of the coagulation system which belongs to peptidase family S1. It is synthesized primarily in the liver and secreted in plasma. Factor IX is produced as a zymogen, an inactive precursor. It is processed to remove the signal peptide, glycosylated and then cleaved by factor XIa (of the contact pathway) or factor VIIa (of the tissue factor pathway) to produce a two-chain form where the chains are linked by a disulfide bridge. Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca2+ ions, phospholipids, and factor VIIIa. Deficiency of this protein causes hemophilia B, An X-linked blood coagulation disorder characterized by a permanent tendency to hemorrhage.