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Data sheet
| Specificity | Antibody recognizes human, mouse, rat cardiac troponin I (cTnI) |
| Size | 100 µg |
| Storage | 2 - 8 ℃ |
| Application | Western blot, ELISA, IHC |
| Immunogen/Antigen | N-terminal region of human cTnI |
| Cross Reactivity | human, mouse, rat |
| Isotype | IgG1 |
| Reactivity | only cardiac Troponin I, not skeletal muscle Troponin I |
| Host Species | mouse |
| Supplied In | PBS, pH 7.2, 0.02% NaN3 as a preservative |
| Dilution & Recommended Usage | WB, 1:500; ELISA, 1:10:000. |
| Protein Background | Troponin I (TnI), troponin T (TnT) and troponin C (TnC) form the troponin complex of the thin filaments of striated muscle. TnI is acts as the inhibitory subunit by blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains 3 genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. The TNNI3 gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in the TNNI3 gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM). |