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Data sheet
| Formulation | The CDKN2C solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 200mM NaCl, 2mM DTT and 10% glycerol. |
| Purity | Greater than 95% as determined by SDS-PAGE. |
| Description | CDKN2C Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 192 amino acids (1-168 and having a molecular mass of 20.7kDa.CDKN2C is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. |
| Protein Background | CDKN2C is a member of the CDKN2 cyclin-dependent kinase inhibitor family. CDKN2C cooperates with CDK4 or CDK6, and inhibits the activation of the CDK kinases, therefore acts as a cell growth regulator which regulates cell cycle G1 progression. CDKN2C suppresses the cell growth and proliferation with a correlated dependency on endogenous retinoblastoma protein RB. Studies in the knockout mice show CDKN2C takes part in regulating spermatogenesis, in addition to suppressing tumorigenesis. |
| Expression host | E.coli. |
| Synonyms | Cyclin-dependent kinase inhibitor 2C (p18 inhibits CDK4), cyclin-dependent kinase 4 inhibitor C, cyclin-dependent kinase 6 inhibitor p18, INK4C, p18, p18-INK6, p18-INK4C, CDK6 inhibitor p18, cyclin-dependent inhibitor, CDKN6, p18-INK4c. |
| Reagent Appearance | Sterile Filtered colorless solution. |
| Stability | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Amino acid sequence | MGSSHHHHHH SSGLVPRGSH MGSHMAEPWG NELASAAARG DLEQLTSLLQ NNVNVNAQNG FGRTALQVMK LGNPEIARRL LLRGANPDLK DRTGFAVIHD AARAGFLDTL QTLLEFQADV NIEDNEGNLP LHLAAKEGHL RVVEFLVKHT ASNVGHRNHK GDTACDLARL YGRNEVVSLM QANGAGGATN LQ |
| Quality Control Test | MLPVNSPMNK GDTEVMKCIV EVISDTLSKP SPMPVSQECF ETLRGDERIL SILRHQNLLK ELQDLALQGA KERAHQQKKH SGFEDELSEV LENQSSQAEL KEAVEEPSSK DVME. |
More info
CDK6 inhibitor p18, CDKN6, cyclin-dependent inhibitor, cyclin-dependent kinase 4 inhibitor C, cyclin-dependent kinase 6 inhibitor p18, INK4C, p18, p18-INK4c, p18-INK4C, p18-INK6, Cyclin-dependent kinase inhibitor 2C (p18 inhibits CDK4)