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Platelet Factor-4 Mouse Recombinant ( CXCL4 ) ( PF 4 Mouse )
DescriptionCXCL4 Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 73 amino acids and having a molecular mass of 8.2 kDa.SourceEscherichia Coli.Physical AppearanceSterile Filtered white lyophilized
Data sheet
| Formulation | The Mouse CXCL4 protein was lyophilized from a 0.2um filtered concentrated solution in 20mM PB, pH 7.4 and 1.0M NaCl. |
| Solubility | It is recommended to reconstitute the lyophilized CXCL4 in sterile 18M-cm H2O not less than 100ug/ml, which can then be further diluted to other aqueous solutions. |
| Purity | Greater than 97.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE. |
| Description | CXCL4 Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 76 amino acids and having a molecular mass of 8.2kDa. |
| Protein Background | Platelet factor-4 is a 70-amino acid protein that is released from the alpha-granules of activated platelets and binds with high affinity to heparin. Its major physiologic role appears to be neutralization of heparin-like molecules on the endothelial surface of blood vessels, thereby inhibiting local antithrombin III activity and promoting coagulation. As a strong chemoattractant for neutrophils and fibroblasts, PF4 probably has a role in inflammation and wound repair. Oncostatin-A is a member of the CXC chemocinfamily. Human PF4 is used for the proof of heparin-induced thrombocytopenia. Furthermore it is used as an inhibitor in the angiogenesis during tumor therapy. |
| Expression host | Escherichia Coli. |
| Synonyms | CXCL4, PF-4, PF4, Iroplact, Oncostatin-A, SCYB4, MGC138298. |
| Reagent Appearance | Sterile Filtered white lyophilized powder. |
| Stability | Lyophilized CXCL4 Mouse Recombinant although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Mouse CXCL4 should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles. |
| Amino acid sequence | VTSAGPEESD GDLSCVCVKT ISSGIHLKHI TSLEVIKAGR HCAVPQLIAT LKNGRKICLD RQAPLYKKVI KKILES. |