Human SOD1 / Superoxide Dismutase ELISA Kit

Cu/Zn superoxide dismutase (SOD1) is an abundant enzyme that has been best studied as a regulator of antioxidant defense. SOD1 binds copper and zinc ions and is one of three superoxide dismutases responsible for destroying free superoxide radicals which are normally produced within the cells and which are toxic to biological systems. SOD1 is a soluble cytoplasmic and mitochondrial intermembrane space protein, acting as a homodimer to convert naturally occurring, but harmful, superoxide radicals to molecular oxygen and hydrogen peroxide. Hydrogen peroxide can then be broken down by another enzyme called catalase. The other isozyme is a mitochondrial protein. Mutations in SOD1 have been implicated as causes of familial amyotrophic lateral sclerosis.