Human CD150/SLAM/SLAMF1 ELISA Kit

CD150/signaling lymphocytic activation molecule (SLAM) is a cell surface phosphoglycoprotein and belongs to the CD2 subset of the Ig superfamily of type I transmembrane glycoproteins. It is constitutively expressed on peripheral blood memory T-cells, T-cell clones, immature thymocytes and a proportion of B-cells, and is rapidly induced on naive T-cells after activation. CD150 is an important high-affinity self-ligand in bidirectional T-cell to B-cell stimulation. SLAM-induced signal-transduction events in T-lymphocytes are different from those in B-cells. There are two SLAM signalings: one in which the inhibitor SH2D1A acts as a negative regulator and the other in which protein-tyrosine phosphatase 2C (PTPN11)-dependent signal transduction operates.