TRPV3 Antibody

Overview

Long Name	Antibody Type	Antibody Isotype	Host	Species Reactivity	Validated Applications	Purification
transient receptor potential cation channel, subfamily V, member 3	Polyclonal	IgG	Rabbit	Human	WB	Immunogen affinity purified.
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human TRPV3(757-773aa RRTDFNKIQDSSRNNSK), different from the related rat and mouse sequences by four amino acids.

Properties

Form	Lyophilized
Size	100 µg/vial
Contents	Antibody is lyophilized with 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal and 0.05 mg NaN3. *carrier free antibody available upon request.
Concentration	Reconstitute with 0.2 mL sterile dH2O (500 µg/ml final concentration).
Storage	At -20 °C for 12 months, as supplied. Store reconstituted antibody at 2-8 °C for one month. For long-term storage, aliquot and store at -20 °C. Avoid repeated freezing and thawing.

Additional Information Regarding the Antigen

Gene	TRPV3
Protein	Transient receptor potential cation channel subfamily V member 3
Uniprot ID	Q8NET8
Function	Putative receptor-activated non-selective calcium permeant cation channel. It is activated by innocuous (warm) temperatures and shows an increased response at noxious temperatures greater than 39 degrees Celsius. Activation exhibits an outward rectification. May associate with TRPV1 and may modulate its activity. Is a negative regulator of hair growth and cycling: TRPV3-coupled signaling suppresses keratinocyte proliferation in hair follicles and induces apoptosis and premature hair follicle regression (catagen).
Tissue Specificity	Abundantly expressed in CNS. Widely expressed at low levels. Detected in dorsal root ganglion (at protein level). Expressed in the keratinocyte layers of the outer root sheath and, to lesser extent, to the matrix of the hair follicles (at protein level).
Sub-cellular localization	Membrane; Multi-pass membrane protein.
Sequence Similarities	Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV3 sub-subfamily.
Aliases	1110036I10Rik antibody|MGC124324 antibody|MGC124325 antibody|Transient receptor potential cation channel subfamily V member 3 antibody|TrpV3 antibody|Trpv3 heat sensitive channel antibody|TRPV3_HUMAN antibody|Vanilloid receptor 3 antibody|Vanilloid receptor like 3 antibody|Vanilloid receptor-like 3 antibody|vanilloid receptor-related osmotically activated channel protein antibody|VRL 3 antibody|VRL-3 antibody|VRL3 antibody

Application Details

Application	Concentration*	Species	Validated Using**
Western blot	0.1-0.5μg/ml	Human	AssaySolutio's ECL kit

AssaySolution recommends Rabbit Chemiluminescent WB Detection Kit (AKIT001B) for Western blot. *Blocking peptide can be purchased at $65. Contact us for more information